Effects of cisapride on QTc interval in term neonates
نویسندگان
چکیده
منابع مشابه
Effects of cisapride on QTc interval in term neonates.
BACKGROUND Cisapride administration for 48 hours has been shown to increase heart rate corrected QT (QTc) interval in preterm neonates. Accumulation of the drug because of liver enzyme immaturity has been suggested to be the reason. If this is correct, a longer survey of QTc interval should disclose an increase even in term neonates. OBJECTIVE A prospective survey of the effects of cisapride ...
متن کاملEffects of cisapride on QTc interval in neonates.
AIM Prospective survey of the effects of cisapride on QTc interval in neonates given cisapride. METHODS QTc interval was determined just before and 2.9 (0.9) days after outset of the treatment in 49 neonates treated with cisapride between 1 August 1995 and 29 February 1996. RESULTS Cisapride significantly increased QTc interval (p = 0.0001), and this was higher when birthweight or gestation...
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15 صفحه اولEffects of cisapride on QT interval in children.
Recent reports of torsade de pointes and heart block associated with prolonged QT interval in children receiving cisapride raise questions about its safety. We prospectively examined the effects of cisapride on the QT interval in children. Electrocardiography was performed on 30 children before and after cisapride was administered. An additional 71 children underwent electrocardiography only af...
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A single-dose, randomized, double-blind, placebo- and positive-controlled, three-period crossover study was conducted to evaluate the effect of peginesatide injection on QT interval in healthy adults. Subjects received single doses of placebo, peginesatide injection 0.1 mg/kg intravenous, or moxifloxacin 400 mg during three treatment periods, separated by 14-day washout intervals. ECG recording...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood - Fetal and Neonatal Edition
سال: 2001
ISSN: 1359-2998
DOI: 10.1136/fn.84.1.f44